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Abstract Background p27Kip1 plays a major role as a negative regulator of the cell cycle.The regulation of p27Kip1 degradation is mediated by its specific ubiquitin ligase subunits S-phase kinase protein (Skp) 2 and cyclin-dependent kinase subunit (Cks) 1.However, little is known regarding the prognostic utility of p27Kip1, Skp2 and Cks1 expression

The ultrastructure of pristine shells of Jurassic and Cretaceous lytoceratid and perisphinctid ammonoids indicates that flares and parabolae represent homologous structures.Both mark an interruption of shell growth.We dismiss jolly joes grape candy earlier interpretations of parabolae as actual aperture, relics of resorbed apophyses or superstructu

Nephronophthisis (NPH) is an autosomal recessive ciliopathy and a major cause of end-stage renal disease in children.The main forms, juvenile and adult NPH, are characterized by tubulointerstitial fibrosis whereas the infantile form is more severe and characterized by cysts.NPH is caused by mutations faux parlor palm in over 20 different genes, mos